Sequence Detail

ID/Version

Q9Z2G1 Q3U2C2 Q8CBW9 Q8C6D9 Q9DBC6 Q8C4V3 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Protein fem-1 homolog A-A {ECO:0000305}; Short=FEM1a-A {ECO:0000305};AltName: Full=FEM1-alpha-A {ECO:0000305};AltName: Full=Prostaglandin E receptor 4-associated protein {ECO:0000303|PubMed:18270204};

Provider

SWISS-PROT

Sequence

Polypeptide 654 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fem1a	fem 1 homolog a	22	100	3	6

Sequence references in MGI

J:51387 Ventura-Holman T, et al., The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics. 1998 Dec 1;54(2):221-30
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:135247 Minami M, et al., Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem. 2008 Apr 11;283(15):9692-703
J:228893 Nakatsuji M, et al., EP4 Receptor-Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis. PLoS Genet. 2015 Oct;11(10):e1005542
J:244450 Fujikawa R, et al., Deficiency in EP4 Receptor-Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease. Am J Pathol. 2017 Aug;187(8):1848-1854
J:253904 Fujikawa R, et al., Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice. Biochem Biophys Res Commun. 2017 Apr 29;486(2):584-588
J:304242 Fujikawa R, et al., EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain. Am J Pathol. 2016 Aug;186(8):1982-1988
J:304573 Cambier L, et al., Fem1a is a mitochondrial protein up-regulated upon ischemia-reperfusion injury. FEBS Lett. 2009 May 19;583(10):1625-30
J:319834 Higuchi S, et al., EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice. J Immunol. 2016 Dec 1;197(11):4436-4443