Sequence Detail

ID/Version

Q9R194 O08706 Q6A024 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Cryptochrome-2;

Provider

SWISS-PROT

Sequence

Polypeptide 592 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cry2	cryptochrome circadian regulator 2	102	106	3	22

Sequence references in MGI

J:51295 Kobayashi K, et al., Characterization of photolyase/blue-light receptor homologs in mouse and human cells. Nucleic Acids Res. 1998 Nov 15;26(22):5086-92
J:57719 Miyamoto Y, et al., Circadian regulation of cryptochrome genes in the mouse. Brain Res Mol Brain Res. 1999 Aug 25;71(2):238-43
J:73655 Lee C, et al., Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28;107(7):855-67
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101219 Harada Y, et al., Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3beta. J Biol Chem. 2005 Sep 9;280(36):31714-21
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:120341 Ohno T, et al., The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1010-5
J:122872 Siepka SM, et al., Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell. 2007 Jun 1;129(5):1011-23
J:147991 Ramsey KM, et al., Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009 May 1;324(5927):651-4
J:154857 Chen R, et al., Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell. 2009 Nov 13;36(3):417-30
J:161722 Kurabayashi N, et al., DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol Cell Biol. 2010 Apr;30(7):1757-68
J:177241 Ozber N, et al., Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol. 2010;11:69
J:179376 Lamia KA, et al., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 22;480(7378):552-6
J:194037 Yoo SH, et al., Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell. 2013 Feb 28;152(5):1091-105
J:196293 Hirano A, et al., FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell. 2013 Feb 28;152(5):1106-18
J:196953 Anand SN, et al., Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. J Neurosci. 2013 Apr 24;33(17):7145-53
J:198214 Barclay JL, et al., High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1053-63
J:200446 Xing W, et al., SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature. 2013 Apr 4;496(7443):64-8
J:204645 Zhao WN, et al., CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar;9(3):268-75
J:205048 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704
J:207239 Gao P, et al., Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length. J Biol Chem. 2013 Dec 6;288(49):35277-86
J:209472 Ono D, et al., Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus. Nat Commun. 2013;4:1666
J:209480 Zhang EE, et al., Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct;16(10):1152-6
J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
J:240095 Shi G, et al., Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep. 2016 Feb 02;14(4):823-34
J:244975 Kriebs A, et al., Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781
J:255965 Jordan SD, et al., CRY1/2 Selectively Repress PPARdelta and Limit Exercise Capacity. Cell Metab. 2017 Jul 5;26(1):243-255.e6
J:273529 Wong JCY, et al., Differential roles for cryptochromes in the mammalian retinal clock. FASEB J. 2018 Aug;32(8):4302-4314
J:283196 Hirano A, et al., USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS One. 2016;11(4):e0154263