Sequence Detail

ID/Version

Q9QZE2 Q8C479 Q9JMJ3 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cytokine-dependent hematopoietic cell linker {ECO:0000303|PubMed:10562326};AltName: Full=Mast cell immunoreceptor signal transducer {ECO:0000250|UniProtKB:Q7Z7G1};

Provider

SWISS-PROT

Sequence

Polypeptide 435 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clnk	cytokine-dependent hematopoietic cell linker	24	96	2	13

Sequence references in MGI

J:58498 Cao MY, et al., Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. J Exp Med. 1999 Nov 15;190(10):1527-34
J:76319 Goitsuka R, et al., A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. Int Immunol. 2000 Apr;12(4):573-80
J:82731 Fujii Y, et al., Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 2003 Apr 10;540(1-3):111-6
J:91590 Utting O, et al., Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Mol Cell Biol. 2004 Jul;24(13):6067-75
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131738 Sasanuma H, et al., Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood. 2006 May 1;107(9):3647-55
J:277871 Xu M, et al., Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. Biochem Biophys Res Commun. 2015 Jul 31;463(3):275-9