Sequence Detail

ID/Version

Q9JJX7 A2RTH9 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosyl-DNA phosphodiesterase 2; Short=Tyr-DNA phosphodiesterase 2; EC=3.1.4.- {ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339};AltName: Full=5'-tyrosyl-DNA

Provider

SWISS-PROT

Sequence

Polypeptide 370 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tdp2	tyrosyl-DNA phosphodiesterase 2	55	104	3	11

Sequence references in MGI

J:62785 Pype S, et al., TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. J Biol Chem. 2000 Jun 16;275(24):18586-93
J:199691 Zeng Z, et al., TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Res. 2012 Sep 1;40(17):8371-80
J:243480 Gomez-Herreros F, et al., TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nat Genet. 2014 May;46(5):516-21
J:246739 Schellenberg MJ, et al., Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res. 2016 May 05;44(8):3829-44