Sequence Detail

ID/Version

Q9JI39 Q542P7 Q9D0C7 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=ATP-binding cassette sub-family B member 10, mitochondrial {ECO:0000305};AltName: Full=ABC-mitochondrial erythroid protein {ECO:0000303|PubMed:10835348}; Short=ABC-me protein {ECO:0000303|PubMed:10835348};AltName: Full=ATP-binding ca

Provider

SWISS-PROT

Sequence

Polypeptide 715 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcb10	ATP-binding cassette, sub-family B member 10	28	101	3	8

Sequence references in MGI

J:62659 Shirihai OS, et al., ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 2000 Jun 1;19(11):2492-502
J:93963 Graf SA, et al., Targeting, Import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004 Oct 8;279(41):42954-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:153237 Chen W, et al., Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16263-8
J:162800 Chen W, et al., Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood. 2010 Jul 29;116(4):628-30
J:204639 Hyde BB, et al., The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 2012 Jul;19(7):1117-26
J:223428 Yamamoto M, et al., Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. Mol Cell Biol. 2014 Mar;34(6):1077-84
J:245995 Seguin A, et al., Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes. J Biol Chem. 2017 Sep 29;292(39):16284-16299
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304048 Qiu W, et al., ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione. PLoS One. 2015;10(6):e0129772
J:304585 Maio N, et al., Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica. 2019 Sep;104(9):1756-1767