Sequence Detail

ID/Version

Q9JHL0 Q9JJ29 Q3UYF6 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Linker for activation of T-cells family member 2;AltName: Full=Linker for activation of B-cells;AltName: Full=Membrane-associated adapter molecule;AltName: Full=Non-T-cell activation linker;AltName: Full=Williams-Beuren syndrome chromosomal

Provider

SWISS-PROT

Sequence

Polypeptide 203 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lat2	linker for activation of T cells family, member 2	32	97	2	12

Sequence references in MGI

J:64707 Martindale DW, et al., Comparative genomic sequence analysis of the williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome. 2000 Oct;11(10):890-8
J:66919 Doyle JL, et al., Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet Cell Genet. 2000;90(3-4):285-90
J:93888 Stork B, et al., Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes. Immunity. 2004 Nov;21(5):681-91
J:93950 Volna P, et al., Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):1001-13
J:93951 Zhu M, et al., Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991-1000
J:98894 Wang Y, et al., Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function. Mol Cell Biol. 2005 Jun;25(11):4455-65
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121605 Janssen E, et al., LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol. 2003 Feb;4(2):117-23
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54