Sequence Detail

ID/Version

Q9DBH0 Q8BTG4 Q923F6 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NEDD4-like E3 ubiquitin-protein ligase WWP2; EC=2.3.2.26;AltName: Full=HECT-type E3 ubiquitin transferase WWP2;AltName: Full=WW domain-containing protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 870 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wwp2	WW domain containing E3 ubiquitin protein ligase 2	64	99	3	379

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:123616 Li H, et al., Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. Mol Cell Biol. 2007 Aug;27(15):5296-305
J:142420 Foot NJ, et al., Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008 Nov 15;112(10):4268-75
J:153775 Chen A, et al., The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol. 2009 Oct;29(19):5348-56
J:163434 Liao B, et al., Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Cell Res. 2010 Mar;20(3):332-44