Sequence Detail

ID/Version

Q9CS84 G3UWZ9 O88722 Q8CHE6 Q80Y87 (UniProt | EBI)

Last sequence update: 2005-12-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Neurexin-1;AltName: Full=Neurexin I-alpha;AltName: Full=Neurexin-1-alpha;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1514 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nrxn1	neurexin I	117	114	4	25

Sequence references in MGI

J:45298 Geppert M, et al., Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem. 1998 Jan 16;273(3):1705-10
J:67898 Fukuda M, et al., Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII). Biochem J. 2001 Mar 1;354(Pt 2):249-57
J:68115 Fukuda M, et al., Synaptotagmin-like protein 1-3: a novel family of c-terminal-type tandem c2 proteins. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1226-33
J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
J:88641 Kattenstroth G, et al., Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2607-12
J:89452 Missler M, et al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003 Jun 26;423(6943):939-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107025 Sons MS, et al., alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction. Neuroscience. 2006;138(2):433-46
J:113228 Dudanova I, et al., Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci. 2006 Oct 11;26(41):10599-613
J:132844 Dudanova I, et al., Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation. J Comp Neurol. 2007 May 10;502(2):261-74
J:134615 Bolliger MF, et al., Unusually rapid evolution of Neuroligin-4 in mice. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6421-6
J:153748 Etherton MR, et al., Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17998-8003
J:177327 Matsuda K, et al., Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur J Neurosci. 2011 Apr;33(8):1447-61
J:201987 Pettem KL, et al., The Specific alpha-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development. Neuron. 2013 Oct 2;80(1):113-28
J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
J:277096 Zhang P, et al., Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018 Sep 6;174(6):1450-1464.e23
J:291190 Kim H, et al., Calsyntenin-3 interacts with both alpha- and beta-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways. J Biol Chem. 2020 Jul 3;295(27):9244-9262
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89