Sequence Detail

ID/Version

Q9CQM9 Q5I0V8 Q9JLZ2 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Glutaredoxin-3;AltName: Full=PKC-interacting cousin of thioredoxin; Short=PICOT;AltName: Full=PKC-theta-interacting protein; Short=PKCq-interacting protein;AltName: Full=Thioredoxin-like protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 337 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Glrx3	glutaredoxin 3	25	102	3	18

Sequence references in MGI

J:60175 Witte S, et al., Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem. 2000 Jan 21;275(3):1902-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:123657 Jeong D, et al., PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circ Res. 2006 Aug 4;99(3):307-14
J:143577 Cha H, et al., PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility. J Mol Cell Cardiol. 2008 Dec;45(6):796-803
J:161906 Jeong D, et al., PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling. Circ Res. 2008 Mar 28;102(6):711-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89