Sequence Detail

ID/Version

Q922Z0 Q2UVA9 Q3TT69 Q0E9Q7 Q8R2R2 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=D-aspartate oxidase; Short=DASOX; Short=DASPO {ECO:0000303|PubMed:17469229}; Short=DDO {ECO:0000303|PubMed:20567862}; EC=1.4.3.1 {ECO:0000269|PubMed:16516413, ECO:0000269|PubMed:17469229, ECO:0000269|PubMed:18

Provider

SWISS-PROT

Sequence

Polypeptide 341 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddo	D-aspartate oxidase	51	101	3	7

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106267 Huang AS, et al., D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 8;26(10):2814-9
J:109184 Errico F, et al., A physiological mechanism to regulate d-aspartic acid and NMDA levels in mammals revealed by d-aspartate oxidase deficient mice. Gene. 2006 Jun 7;374:50-7
J:110631 Weil ZM, et al., Behavioural alterations in male mice lacking the gene for D-aspartate oxidase. Behav Brain Res. 2006 Aug 10;171(2):295-302
J:176710 Errico F, et al., Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay. Neurobiol Aging. 2011 Nov;32(11):2061-74
J:188896 Katane M, et al., Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment. Biochimie. 2010 Oct;92(10):1371-8
J:231660 Punzo D, et al., Age-Related Changes in d-Aspartate Oxidase Promoter Methylation Control Extracellular d-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging. J Neurosci. 2016 Mar 9;36(10):3064-78
J:278140 Nuzzo T, et al., Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity. Exp Neurol. 2019 Jul;317:51-65
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:307596 De Rosa A, et al., Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood. Amino Acids. 2020 Apr;52(4):597-617
J:343113 Santillo A, et al., D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice. Biomolecules. 2023 Mar 30;13(4)
J:343144 Lombardo B, et al., D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans. Transl Psychiatry. 2022 Aug 1;12(1):305
J:343392 Katane M, et al., Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes. Biol Pharm Bull. 2015;38(2):298-305
J:343396 Sacchi S, et al., Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity. Sci Rep. 2017 Apr 10;7:46288
J:343397 Puggioni V, et al., Biochemical characterization of mouse d-aspartate oxidase. Biochim Biophys Acta Proteins Proteom. 2020 Oct;1868(10):140472
J:343403 Katane M, et al., Hyperactive mutants of mouse D-aspartate oxidase: mutagenesis of the active site residue serine 308. Amino Acids. 2008 Jun;35(1):75-82
J:343404 Katane M, et al., Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase. Amino Acids. 2011 Feb;40(2):467-76
J:343409 Han H, et al., Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52