Sequence Detail

ID/Version

Q91YT8 Q69ZZ1 Q3TCS5 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Mechanosensitive cation channel TMEM63A {ECO:0000305};AltName: Full=Transmembrane protein 63A;

Provider

SWISS-PROT

Sequence

Polypeptide 804 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tmem63a	transmembrane protein 63a	35	96	3	26

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:281192 Murthy SE, et al., OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels. Elife. 2018 Nov 1;7:e41844
J:281455 Zhao X, et al., Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Cell Biochem Funct. 2016 Jun;34(4):238-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:303483 Du H, et al., The Cation Channel TMEM63B Is an Osmosensor Required for Hearing. Cell Rep. 2020 May 5;31(5):107596
J:343114 Zheng W, et al., TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. 2023 Jul 28;
J:346997 Chen GL, et al., Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion. J Clin Invest. 2024 Dec 21;134(5):e174508
J:361730 Li K, et al., Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels. Nat Cell Biol. 2024 Mar;26(3):393-403
J:362050 Lowry AJ, et al., TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids. Elife. 2024 Nov 4;13