Sequence Detail

ID/Version

Q91WL8 Q920Y2 Q9D2B3 Q9D339 Q9JLF5 Q8C8J6 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=WW domain-containing oxidoreductase; EC=1.1.1.-;

Provider

SWISS-PROT

Sequence

Polypeptide 414 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wwox	WW domain-containing oxidoreductase	50	107	3	36

Sequence references in MGI

J:67264 Chang NS, et al., Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem. 2001 Feb 2;276(5):3361-70
J:76101 Krummel KA, et al., The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1. Genes Chromosomes Cancer. 2002 Jun;34(2):154-67
J:89992 Chen ST, et al., Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system. Neuroscience. 2004;124(4):831-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105906 Chang NS, et al., WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem. 2005 Dec 30;280(52):43100-8
J:120064 Aqeilan RI, et al., Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3949-54
J:138140 Aqeilan RI, et al., The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008 Aug 1;283(31):21629-39
J:150686 Hsu LJ, et al., Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem. 2009 Jun 5;284(23):16049-59
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89