Sequence Detail

ID/Version

Q91V17 Q8C5D7 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase ZNRF1; EC=2.3.2.27;AltName: Full=Nerve injury-induced gene 283 protein;AltName: Full=RING-type E3 ubiquitin transferase ZNRF1;AltName: Full=Zinc/RING finger protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 227 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Znrf1	zinc and ring finger 1	23	101	3	54

Sequence references in MGI

J:74950 Araki T, et al., Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. J Biol Chem. 2001 Sep 7;276(36):34131-41
J:86224 Araki T, et al., ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. J Neurosci. 2003 Oct 15;23(28):9385-94
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:180612 Wakatsuki S, et al., ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol. 2011 Dec;13(12):1415-23
J:250572 Lee CY, et al., The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation. Nat Commun. 2017 Jun 08;8:15502
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335622 Lin YS, et al., The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage. J Exp Med. 2023 Aug 7;220(8)