Sequence Detail

ID/Version

Q8VIM5 Q6W8X1 Q5SS65 Q8VIL4 Q8C3W6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Myocardin;AltName: Full=Basic SAP coiled-coil transcription activator 2;AltName: Full=SRF cofactor protein;

Provider

SWISS-PROT

Sequence

Polypeptide 935 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Myocd	myocardin	112	119	3	16

Sequence references in MGI

J:70265 Wang D, et al., Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001 Jun 29;105(7):851-62
J:82506 Du KL, et al., Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol. 2003 Apr;23(7):2425-37
J:83853 Wang DZ, et al., Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14855-60
J:86864 Ueyama T, et al., Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis. Mol Cell Biol. 2003 Dec;23(24):9222-32
J:95385 Cao D, et al., Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111229 Creemers EE, et al., Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell. 2006 Jul 7;23(1):83-96
J:162813 Imamura M, et al., Expression and functional activity of four myocardin isoforms. Gene. 2010 Sep 15;464(1-2):1-10
J:283803 Houweling AC, et al., Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2;129(12):5374-5380
J:343405 Ferris LA, et al., Purine-rich element binding protein B attenuates the coactivator function of myocardin by a novel molecular mechanism of smooth muscle gene repression. Mol Cell Biochem. 2021 Aug;476(8):2899-2916