Sequence Detail

ID/Version

Q8VDU0 Q8BLX3 (UniProt | EBI)

Last sequence update: 2010-04-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=G-protein-signaling modulator 2;AltName: Full=Pins homolog {ECO:0000303|PubMed:12571286};

Provider

SWISS-PROT

Sequence

Polypeptide 679 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpsm2	G-protein signalling modulator 2 (AGS3-like, C. elegans)	71	120	4	18

Sequence references in MGI

J:82278 Yu F, et al., A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. J Cell Sci. 2003 Mar 1;116(Pt 5):887-96
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:200468 Pan Z, et al., Structural and biochemical characterization of the interaction between LGN and Frmpd1. J Mol Biol. 2013 Mar 25;425(6):1039-49
J:228108 Jia M, et al., Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai. J Biol Chem. 2012 Oct 26;287(44):36766-76
J:239972 Chiu CW, et al., SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Galphai-LGN-NuMA Ternary Complex. Dev Cell. 2016 Jan 11;36(1):50-62
J:247410 Pan Z, et al., An autoinhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs. Structure. 2013 Jun 04;21(6):1007-17
J:282162 Gresakova V, et al., [Retracted] Fam208a orchestrates interaction protein network essential for early embryonic development and cell division. Exp Cell Res. 2019 Sep 1;382(1):111437
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89