Sequence Detail

ID/Version

Q8VD75 Q571K7 Q3TLS2 (UniProt | EBI)

Last sequence update: 2009-01-20
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Huntingtin-interacting protein 1 {ECO:0000250|UniProtKB:O00291}; Short=HIP-1;AltName: Full=Huntingtin-interacting protein I; Short=HIP-I {ECO:0000250|UniProtKB:O00291};

Provider

SWISS-PROT

Sequence

Polypeptide 1029 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hip1	huntingtin interacting protein 1	74	102	3	31

Sequence references in MGI

J:72637 Rao DS, et al., Huntingtin Interacting Protein 1 Is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic Progenitors. Mol Cell Biol. 2001 Nov;21(22):7796-806
J:73120 Mishra SK, et al., Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. J Biol Chem. 2001 Dec 7;276(49):46230-6
J:84278 Metzler M, et al., Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J. 2003 Jul 1;22(13):3254-66
J:90400 Oravecz-Wilson KI, et al., Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet. 2004 Apr 15;13(8):851-67
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:119220 Khatchadourian K, et al., Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice. Mol Reprod Dev. 2007 Mar;74(3):341-59
J:119798 Metzler M, et al., NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1. J Neurosci. 2007 Feb 28;27(9):2298-308
J:121739 Bradley SV, et al., Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. Hum Mol Genet. 2007 Jun 1;16(11):1279-92
J:125695 Parker JA, et al., Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity. J Neurosci. 2007 Oct 10;27(41):11056-64
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89