Sequence Detail

ID/Version

Q8K3Z0 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2 {ECO:0000303|PubMed:12835899};AltName: Full=Caspase recruitment domain-containing protein 15 {ECO:0000303|PubMed:12835899};

Provider

SWISS-PROT

Sequence

Polypeptide 1020 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nod2	nucleotide-binding oligomerization domain containing 2	230	96	3	22

Sequence references in MGI

J:96035 Kobayashi KS, et al., Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005 Feb 4;307(5710):731-4
J:96128 Maeda S, et al., Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 4;307(5710):734-8
J:117799 Hsu YM, et al., The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb;8(2):198-205
J:153244 Petnicki-Ocwieja T, et al., Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15813-8
J:157879 Travassos LH, et al., Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010 Jan;11(1):55-62
J:169881 Hsu LC, et al., A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7803-8
J:175223 Magalhaes JG, et al., Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14896-901
J:186805 Schertzer JD, et al., NOD1 activators link innate immunity to insulin resistance. Diabetes. 2011 Sep;60(9):2206-15
J:188020 Damgaard RB, et al., The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58
J:194452 Rehman A, et al., Nod2 is essential for temporal development of intestinal microbial communities. Gut. 2011 Oct;60(10):1354-62
J:194501 Couturier-Maillard A, et al., NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 2013 Feb;123(2):700-11
J:204062 Jiang W, et al., Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med. 2013 Oct 21;210(11):2465-76
J:221560 McDonald C, et al., A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem. 2005 Dec 2;280(48):40301-9
J:230689 Dugan J, et al., Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice. J Immunol. 2015 Jan 1;194(1):349-57
J:232669 Denou E, et al., Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance. EMBO Mol Med. 2015 Mar;7(3):259-74
J:233999 Ramanan D, et al., Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity. 2014 Aug 21;41(2):311-24
J:284106 Levy A, et al., Innate immune receptor NOD2 mediates LGR5(+) intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):1994-2003
J:323343 Gabanyi I, et al., Bacterial sensing via neuronal Nod2 regulates appetite and body temperature. Science. 2022 Apr 15;376(6590):eabj3986
J:328962 Nigro G, et al., The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe. 2014 Jun 11;15(6):792-8
J:335612 Keestra-Gounder AM, et al., NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21;532(7599):394-7
J:335668 Cooney R, et al., NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med. 2010 Jan;16(1):90-7
J:335670 Bereswill S, et al., Campylobacter jejuni infection of conventionally colonized mice lacking nucleotide-oligomerization-domain-2. Gut Pathog. 2017;9:5
J:335673 Stafford CA, et al., Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation. Nature. 2022 Sep;609(7927):590-596
J:340956 Schwarzer M, et al., Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice. Science. 2023 Feb 24;379(6634):826-833