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Sequence Detail
Q8K3Z0 (UniProt | EBI) Last sequence update: 2002-10-01
Last annotation update: 2020-08-12
from provider
RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2;AltName: Full=Caspase recruitment domain-containing protein 15;
Polypeptide 1020 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Nod2 nucleotide-binding oligomerization domain containing 2 144 70 7 16
Sequence references in MGI J:117799 Hsu YM, et al., The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb;8(2):198-205
J:169881 Hsu LC, et al., A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7803-8
J:188020 Damgaard RB, et al., The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58
J:221560 McDonald C, et al., A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem. 2005 Dec 2;280(48):40301-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory