Sequence Detail

ID/Version

Q8CHG7 E9QMD0 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Rap guanine nucleotide exchange factor 2;AltName: Full=Cyclic nucleotide ras GEF; Short=CNrasGEF;AltName: Full=Neural RAP guanine nucleotide exchange protein; Short=nRap GEP;AltName: Full=PDZ domain-containing guanine nucleot

Provider

SWISS-PROT

Sequence

Polypeptide 1496 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rapgef2	Rap guanine nucleotide exchange factor (GEF) 2	110	101	4	20

Sequence references in MGI

J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
J:125199 Wei P, et al., Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2007 Nov 9;363(1):106-12
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:149445 Bilasy SE, et al., Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect. Eur J Neurosci. 2009 May;29(10):1994-2008
J:152727 Kanemura H, et al., Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2009 Oct 2;387(4):754-9
J:178740 Bilasy SE, et al., RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures. Neurosci Res. 2011 Nov;71(3):200-9
J:198912 Amsen EM, et al., The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells. J Biol Chem. 2006 Jan 6;281(1):121-8
J:201420 Emery AC, et al., Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Sci Signal. 2013 Jun 25;6(281):ra51
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89