Sequence Detail

ID/Version

Q8CGC7 Q3UFJ2 Q4VC16 E9QKC4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bifunctional glutamate/proline--tRNA ligase {ECO:0000305};AltName: Full=Bifunctional aminoacyl-tRNA synthetase;Includes: RecName: Full=Glutamate--tRNA ligase {ECO:0000250|UniProtKB:P07814}; EC=6.1.1.17 {ECO:0000250|UniProtKB:P0781

Provider

SWISS-PROT

Sequence

Polypeptide 1512 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eprs1	glutamyl-prolyl-tRNA synthetase 1	84	100	3	35

Sequence references in MGI

J:93041 Kim JY, et al., p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7912-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:192858 Arif A, et al., Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol Cell Biol. 2012 Dec;32(24):5046-55
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:244749 Arif A, et al., EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature. 2017 Feb 16;542(7641):357-361
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89