Sequence Detail

ID/Version

Q8C863 O54971 (UniProt | EBI)

Last sequence update: 2003-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase Itchy; EC=2.3.2.26 {ECO:0000269|PubMed:15358865, ECO:0000269|PubMed:16446428, ECO:0000269|PubMed:17592138, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:25632008};AltName: Fu

Provider

SWISS-PROT

Sequence

Polypeptide 864 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itch	itchy, E3 ubiquitin protein ligase	111	103	4	58

Sequence references in MGI

J:45910 Perry WL, et al., The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice [see comments]. Nat Genet. 1998 Feb;18(2):143-6
J:75315 Harvey KF, et al., N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem. 2002 Mar 15;277(11):9307-17
J:75463 Traweger A, et al., The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch. J Biol Chem. 2002 Mar 22;277(12):10201-8
J:93082 Gao M, et al., Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004 Oct 8;306(5694):271-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108987 Fang D, et al., Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol. 2002 Mar;3(3):281-7
J:116617 Oliver PM, et al., Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity. 2006 Dec;25(6):929-40
J:139281 Chastagner P, et al., AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One. 2008;3(7):e2735
J:143823 Oberst A, et al., The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11280-5
J:163431 Azakir BA, et al., The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. FEBS J. 2010 Mar;277(5):1319-30
J:200471 Mossinger J, et al., Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch. EMBO Rep. 2012 Dec;13(12):1087-94
J:244873 Kathania M, et al., Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015 Mar 01;194(5):2160-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314101 Noyes NC, et al., Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. Biochemistry. 2016 Mar 1;55(8):1204-13