Sequence Detail

ID/Version

Q8C147 Q7TMQ5 Q6PIS0 Q9DBQ2 Q6KAM7 Q8K105 Q8CAP6 (UniProt | EBI)

Last sequence update: 2007-08-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Dedicator of cytokinesis protein 8;

Provider

SWISS-PROT

Sequence

Polypeptide 2100 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dock8	dedicator of cytokinesis 8	44	99	3	27

Sequence references in MGI

J:92574 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Apr 30;11(2):127-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:185165 Harada Y, et al., DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012 May 10;119(19):4451-61
J:220239 Krishnaswamy JK, et al., Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61
J:238772 Xu X, et al., LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017 Jan;214(1):209-226
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89