Sequence Detail

ID/Version

Q8BJS4 Q3TBU0 Q3U160 Q6B4H2 (UniProt | EBI)

Last sequence update: 2010-08-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=SUN domain-containing protein 2;AltName: Full=Protein unc-84 homolog B;AltName: Full=Sad1/unc-84 protein-like 2;

Provider

SWISS-PROT

Sequence

Polypeptide 731 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sun2	Sad1 and UNC84 domain containing 2	40	104	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104409 Crisp M, et al., Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006 Jan 2;172(1):41-53
J:150047 Lei K, et al., SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12
J:154595 Ostlund C, et al., Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci. 2009 Nov 15;122(Pt 22):4099-108
J:155113 Zhang X, et al., SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29;64(2):173-87
J:159127 Haque F, et al., Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010 Jan 29;285(5):3487-98
J:168360 Luxton GW, et al., Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science. 2010 Aug 20;329(5994):956-9
J:168852 Yu J, et al., KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011 Mar 15;20(6):1061-73
J:192230 Razafsky D, et al., LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina. PLoS One. 2012;7(10):e47180
J:197280 Borrego-Pinto J, et al., Samp1 is a component of TAN lines and is required for nuclear movement. J Cell Sci. 2012 Mar 1;125(Pt 5):1099-105
J:211008 Link J, et al., Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. PLoS Genet. 2014 Feb;10(2):e1004099
J:247399 Nie S, et al., Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators. Structure. 2016 Jan 05;24(1):80-91
J:287130 Kozono T, et al., Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins. J Biochem. 2018 Oct 1;164(4):303-311
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89