Sequence Detail

ID/Version

Q6ZQ08 B2RY28 Q8C0H2 Q3UPB7 Q8BXB2 Q8BSB4 Q8K3D8 (UniProt | EBI)

Last sequence update: 2008-01-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=CCR4-NOT transcription complex subunit 1;AltName: Full=CCR4-associated factor 1;

Provider

SWISS-PROT

Sequence

Polypeptide 2375 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cnot1	CCR4-NOT transcription complex, subunit 1	66	104	3	130

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:157579 Suzuki A, et al., NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3594-9
J:196241 Zheng X, et al., Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells. 2012 May;30(5):910-22
J:280232 De Franco E, et al., A Specific CNOT1 Mutation Results in a Novel Syndrome of Pancreatic Agenesis and Holoprosencephaly through Impaired Pancreatic and Neurological Development. Am J Hum Genet. 2019 May 2;104(5):985-989
J:282824 Kruszka P, et al., A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly. Am J Hum Genet. 2019 May 2;104(5):990-993
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:350342 Liu J, et al., YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways. Cell Rep. 2020 Sep 8;32(10):108120