Sequence Detail

ID/Version

Q6NVG5 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Melanoregulin {ECO:0000303|PubMed:17260955, ECO:0000303|PubMed:19240024};AltName: Full=Dilute suppressor protein {ECO:0000303|PubMed:15550542};AltName: Full=Whn-dependent transcript 2 {ECO:0000303|PubMed:19240024};

Provider

SWISS-PROT

Sequence

Polypeptide 214 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mreg	melanoregulin	22	102	3	177

Sequence references in MGI

J:9309 Moore KJ, et al., The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln. Genetics. 1988 Aug;119(4):933-41
J:94728 O'Sullivan TN, et al., dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice. Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16831-6
J:149250 Damek-Poprawa M, et al., Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. J Biol Chem. 2009 Apr 17;284(16):10877-89
J:188412 Wu XS, et al., Melanoregulin regulates a shedding mechanism that drives melanosome transfer from melanocytes to keratinocytes. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2101-9
J:190022 Wu XS, et al., Melanoregulin is stably targeted to the melanosome membrane by palmitoylation. Biochem Biophys Res Commun. 2012 Sep 21;426(2):209-14
J:197308 Ohbayashi N, et al., Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012 Mar 15;125(Pt 6):1508-18
J:266465 Rout AK, et al., The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function. Structure. 2018 Oct 2;26(10):1373-1383.e4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89