Sequence Detail

ID/Version

Q64339 Q8K0H3 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ubiquitin-like protein ISG15;AltName: Full=Interferon-induced 15 kDa protein;AltName: Full=Interferon-induced 17 kDa protein; Short=IP17;AltName: Full=Ubiquitin cross-reactive protein;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 161 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Isg15	ISG15 ubiquitin-like modifier	78	105	3	6

Sequence references in MGI

J:85578 Owhashi M, et al., Identification of a ubiquitin family protein as a novel neutrophil chemotactic factor. Biochem Biophys Res Commun. 2003 Sep 26;309(3):533-9
J:102366 Lenschow DJ, et al., Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol. 2005 Nov;79(22):13974-83
J:119518 Lenschow DJ, et al., IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6
J:142023 Okumura F, et al., Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation. J Biol Chem. 2008 Sep 5;283(36):24484-8
J:165486 Skaug B, et al., Emerging role of ISG15 in antiviral immunity. Cell. 2010 Oct 15;143(2):187-90
J:178099 Maragno AL, et al., ISG15 modulates development of the erythroid lineage. PLoS One. 2011;6(10):e26068
J:183179 Werneke SW, et al., ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. PLoS Pathog. 2011 Oct;7(10):e1002322
J:187590 Bogunovic D, et al., Mycobacterial disease and impaired IFN-gamma immunity in humans with inherited ISG15 deficiency. Science. 2012 Sep 28;337(6102):1684-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304589 Shin D, et al., Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. 2020 Nov;587(7835):657-662