Sequence Detail

ID/Version

Q62315 Q3TPU4 Q99LD1 Q3UHS7 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein Jumonji;AltName: Full=Jumonji/ARID domain-containing protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1234 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Jarid2	jumonji and AT-rich interaction domain containing 2	59	121	4	451

Sequence references in MGI

J:25641 Takeuchi T, et al., Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995 May 15;9(10):1211-22
J:42772 Motoyama J, et al., Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice. Mech Dev. 1997 Aug;66(1-2):27-37
J:57069 Takeuchi T, et al., jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background. Mech Dev. 1999 Aug;86(1-2):29-38
J:63359 Lee Y, et al., Jumonji, a nuclear protein that is necessary for normal heart development [see comments]. Circ Res. 2000 May 12;86(9):932-8
J:86133 Kim TG, et al., JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. J Biol Chem. 2003 Oct 24;278(43):42247-55
J:95125 Kim TG, et al., Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004 Dec;24(23):10151-60
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100923 Jung J, et al., Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J Biol Chem. 2005 Sep 2;280(35):30916-23
J:114180 Toyoda M, et al., Jumonji is a nuclear protein that participates in the negative regulation of cell growth. Biochem Biophys Res Commun. 2000 Aug 2;274(2):332-6
J:122750 Mysliwiec MR, et al., Characterization of zinc finger protein 496 that interacts with Jumonji/Jarid2. FEBS Lett. 2007 Jun 12;581(14):2633-40
J:157630 Peng JC, et al., Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell. 2009 Dec 24;139(7):1290-302
J:157724 Shen X, et al., Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009 Dec 24;139(7):1303-14
J:158991 Pasini D, et al., JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. 2010 Mar 11;464(7286):306-10
J:159133 Shirato H, et al., A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem. 2009 Jan 9;284(2):733-9
J:240581 Iseki H, et al., Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 2016 Feb;34(2):322-33
J:267650 Toyoda M, et al., jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. Dev Cell. 2003 Jul;5(1):85-97
J:287559 Zhang H, et al., DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation. Cell Rep. 2020 Jan 7;30(1):81-97.e7