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Sequence Detail
Q62233 Q4QQQ3 P70176 P70177 (UniProt | EBI) Last sequence update: 1998-12-15
Last annotation update: 2018-01-31
from provider
RecName: Full=Homeobox protein SIX3;AltName: Full=Sine oculis homeobox homolog 3;
Polypeptide 333 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Six3 sine oculis-related homeobox 3 58 65 8 8
Sequence references in MGI J:30342 Oliver G, et al., Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development. 1995 Dec;121(12):4045-55
J:35368 Kawakami K, et al., Identification and expression of six family genes in mouse retina. FEBS Lett. 1996 Sep 16;393(2-3):259-63
J:67049 Lengler J, et al., Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Nucleic Acids Res. 2001 Jan 15;29(2):515-26
J:70282 Lagutin O, et al., Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Dev Dyn. 2001 Jul;221(3):342-9
J:77351 Goudreau G, et al., Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
J:77680 Zhu CC, et al., Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development. 2002 Jun;129(12):2835-49
J:81797 Lagutin OV, et al., Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 2003 Feb 1;17(3):368-79
J:103131 Purcell P, et al., Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns. 2005 Dec;6(1):110-8
J:116102 Liu W, et al., Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J. 2006 Nov 15;25(22):5383-95
J:123470 Manavathi B, et al., Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13128-33
J:130851 Lavado A, et al., Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development. 2008 Feb;135(3):441-50
J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
J:142425 Gaston-Massuet C, et al., Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol. 2008 Dec 15;324(2):322-33
J:162763 Kumar R, et al., Metastasis-Associated Protein 1 and Its Short Form Variant Stimulates Wnt1 Transcription through Promoting Its Derepression from Six3 Corepressor. Cancer Res. 2010 Aug 15;70(16):6649-58
J:165328 Liu W, et al., Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest. 2010 Oct 1;120(10):3568-77
J:178674 Lavado A, et al., Six3 is required for ependymal cell maturation. Development. 2011 Dec;138(24):5291-300
J:200777 Lee B, et al., Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain. Dev Biol. 2013 Sep 15;381(2):491-501
J:212800 Abe Y, et al., EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. Hum Mutat. 2009 Oct;30(10):E946-55
J:212804 Appolloni I, et al., Six3 controls the neural progenitor status in the murine CNS. Cereb Cortex. 2008 Mar;18(3):553-62
J:212815 Carl M, et al., Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development. 2002 Sep;129(17):4057-63

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last database update
MGI 6.11
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