Sequence Detail

ID/Version

Q61790 Q0VBL2 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Lymphocyte activation gene 3 protein {ECO:0000303|PubMed:8921170}; Short=LAG-3 {ECO:0000303|PubMed:8921170};AltName: Full=Activation-induced cytidine deaminase-linked autoimmunity protein {ECO:0000303|PubMed:21300912}; Short=

Provider

SWISS-PROT

Sequence

Polypeptide 521 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lag3	lymphocyte-activation gene 3	33	96	2	36

Sequence references in MGI

J:32509 Miyazaki T, et al., Independent modes of natural killing distinguished in mice lacking Lag3. Science. 1996 Apr 19;272(5260):405-8
J:35771 Mastrangeli R, et al., Cloning of murine LAG-3 by magnetic bead bound homologous probes and PCR (gene-capture PCR). Anal Biochem. 1996 Oct 1;241(1):93-102
J:78576 Workman CJ, et al., Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol. 2002 Aug;32(8):2255-63
J:80063 Workman CJ, et al., Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol. 2002 Nov 15;169(10):5392-5
J:82865 Workman CJ, et al., The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol. 2003 Apr;33(4):970-9
J:89653 Workman CJ, et al., Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol. 2004 May 1;172(9):5450-5
J:93930 Huang CT, et al., Role of LAG-3 in regulatory T cells. Immunity. 2004 Oct;21(4):503-13
J:94361 Li N, et al., Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223). J Immunol. 2004 Dec 1;173(11):6806-12
J:95840 Workman CJ, et al., Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol. 2005 Jan 15;174(2):688-95
J:144806 Workman CJ, et al., LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol. 2009 Feb 15;182(4):1885-91
J:176845 Okazaki T, et al., PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med. 2011 Feb 14;208(2):395-407
J:179341 Bettini M, et al., Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J Immunol. 2011 Oct 1;187(7):3493-8
J:269578 Wang J, et al., Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell. 2019 Jan 10;176(1-2):334-347.e12
J:273527 Li N, et al., Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 2007 Jan 24;26(2):494-504
J:325491 Maruhashi T, et al., Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 2022 May 10;55(5):912-924.e8
J:371374 Du J, et al., Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity. Cell. 2025 Jul 24;188(15):4025-4042.e20
J:371657 Ming Q, et al., LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Nat Immunol. 2022 Jul;23(7):1031-1041
J:371659 Silberstein JL, et al., Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2310866121
J:371665 Jiang Y, et al., Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs. Cell. 2025 May 1;188(9):2354-2371.e18
J:371718 Ming Q, et al., Structural basis for mouse LAG3 interactions with the MHC class II molecule I-A(b). Nat Commun. 2024 Aug 29;15(1):7513