Sequence Detail

ID/Version

Q61575 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Forkhead box protein N1;AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 11; Short=HFH-11; Short=HNF-3/forkhead homolog 11;AltName: Full=Winged-helix transcription factor nude;

Provider

SWISS-PROT

Sequence

Polypeptide 648 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxn1	forkhead box N1	38	141	3	47

Sequence references in MGI

J:466 Kopf-Maier P, et al., Nude mice are not hairless. A morphological study. Acta Anat (Basel). 1990;139(2):178-90
J:21194 Nehls M, et al., New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature. 1994 Nov 3;372(6501):103-7
J:43593 Schorpp M, et al., Characterization of mouse and human nude genes. Immunogenetics. 1997;46(6):509-15
J:155348 Mori K, et al., Foxn1 is essential for vascularization of the murine thymus anlage. Cell Immunol. 2010;260(2):66-9
J:159773 Cheng L, et al., Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem. 2010 Feb 19;285(8):5836-47
J:177992 Nowell CS, et al., Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011 Nov;7(11):e1002348
J:187504 Guo J, et al., Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium. J Mol Med (Berl). 2011 Mar;89(3):263-77
J:202298 Zhang Z, et al., Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis. Int J Biol Sci. 2012;8(8):1156-67
J:207150 Zook EC, et al., Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche. J Immunol. 2013 Dec 1;191(11):5583-93