Sequence Detail

ID/Version

Q61161 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase kinase 2; EC=2.7.11.1;AltName: Full=Germinal center kinase; Short=GCK;AltName: Full=MAPK/ERK kinase kinase kinase 2; Short=MEK kinase kinase 2; Short=MEKKK 2;AltN

Provider

SWISS-PROT

Sequence

Polypeptide 821 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	22	98	4	6

Sequence references in MGI

J:36261 Ren M, et al., In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5151-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:146772 Zhong J, et al., GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. (RETRACTED Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134). Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4372-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89