Sequence Detail

ID/Version

Q60756 Q60788 (UniProt | EBI)

Last sequence update: 2002-11-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor 15 {ECO:0000303|PubMed:8825648}; Short=TCF-15 {ECO:0000303|PubMed:8825648};AltName: Full=Meso1 {ECO:0000303|PubMed:7597044};AltName: Full=Paraxis {ECO:0000303|PubMed:7729571};AltName: Full=Protein bHLH-EC2 {ECO:0

Provider

SWISS-PROT

Sequence

Polypeptide 195 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tcf15	transcription factor 15	35	130	3	10

Sequence references in MGI

J:24364 Burgess R, et al., Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev Biol. 1995 Apr;168(2):296-306
J:26515 Blanar MA, et al., Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5870-4
J:30585 Hidai H, et al., Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. Genomics. 1995 Dec 10;30(3):598-601
J:35897 Quertermous EE, et al., Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7066-70
J:37117 Burgess R, et al., Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature. 1996 Dec 12;384(6609):570-3
J:202837 Rowton M, et al., Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis. Dev Dyn. 2013 Nov;242(11):1332-44
J:234139 Coppiello G, et al., Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake. Circulation. 2015 Mar 3;131(9):815-26
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297822 Rodriguez-Fraticelli AE, et al., Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis. Nature. 2020 Jul;583(7817):585-589
J:302448 Wilson-Rawls J, et al., Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements. J Biol Chem. 2004 Sep 3;279(36):37685-92
J:302456 Davies OR, et al., Tcf15 primes pluripotent cells for differentiation. Cell Rep. 2013 Feb 21;3(2):472-84