Sequence Detail

ID/Version

Q60591 Q60985 B5B2Q3 A2AQC5 A2APK2 Q60984 Q91Y65 A2APK3 A2AQC6 A2AQC7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear factor of activated T-cells, cytoplasmic 2; Short=NF-ATc2; Short=NFATc2;AltName: Full=NFAT pre-existing subunit; Short=NF-ATp;AltName: Full=T-cell transcription factor NFAT1;

Provider

SWISS-PROT

Sequence

Polypeptide 927 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nfatc2	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	91	108	3	17

Sequence references in MGI

J:15443 McCaffrey PG, et al., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29;262(5134):750-4
J:33570 Luo C, et al., Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol. 1996 Jul;16(7):3955-66
J:51755 Hodge MR, et al., NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science. 1996 Dec 13;274(5294):1903-5
J:59243 Ranger AM, et al., The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis [see comments]. J Exp Med. 2000 Jan 3;191(1):9-22
J:87345 Plyte S, et al., Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain. J Biol Chem. 2001 Apr 27;276(17):14350-8
J:119549 Yang XY, et al., Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition. Dev Biol. 2007 Mar 15;303(2):825-37
J:141917 Cante-Barrett K, et al., Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10
J:141959 Vihma H, et al., Alternative splicing and expression of human and mouse NFAT genes. Genomics. 2008 Nov;92(5):279-91
J:204781 Jang EJ, et al., Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. J Immunol. 2013 Jun 1;190(11):5764-70
J:247860 Gao B, et al., The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol. 2017 May 15;198(10):3927-3938
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343111 Ranjan R, et al., The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6(6):754-64