Sequence Detail

ID/Version

Q3TTA7 E9QMY2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase CBL-B; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q13191};AltName: Full=Casitas B-lineage lymphoma proto-oncogene b;AltName: Full=RING-type E3 ubiquitin transferase CBL-B {ECO:0000305};AltName: Full=SH3-binding pr

Provider

SWISS-PROT

Sequence

Polypeptide 982 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cblb	Casitas B-lineage lymphoma b	38	98	3	19

Sequence references in MGI

J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
J:76897 Chiang YJ, et al., Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 2000 Jan 13;403(6766):216-20
J:79550 Krawczyk C, et al., Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000 Oct;13(4):463-73
J:93595 Jeon MS, et al., Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 2004 Aug;21(2):167-77
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120676 Zhang J, et al., Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol. 2002 Sep 1;169(5):2236-40
J:120692 Sohn HW, et al., Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med. 2003 Jun 2;197(11):1511-24
J:125680 Fang D, et al., Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol. 2001 Sep;2(9):870-5
J:281256 Schmid FM, et al., IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases. J Cell Biol. 2018 Jan 2;217(1):151-161
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331430 Janssen E, et al., Immune dysregulation caused by homozygous mutations in CBLB. J Clin Invest. 2022 Oct 17;132(20):e154487