Sequence Detail

ID/Version

Q3TKT4 Q3TUD7 Q6AXG8 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription activator BRG1; EC=3.6.4.-;AltName: Full=ATP-dependent helicase SMARCA4;AltName: Full=BRG1-associated factor 190A; Short=BAF190A;AltName: Full=Protein brahma homolog 1;AltName: Full=SNF2-beta;AltName: Full=SWI/S

Provider

SWISS-PROT

Sequence

Polypeptide 1613 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	191	149	3	81

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105941 Ohkawa Y, et al., Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. EMBO J. 2006 Feb 8;25(3):490-501
J:132090 Lessard J, et al., An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007 Jul 19;55(2):201-15
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:166998 Miller SA, et al., Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell. 2010 Nov 24;40(4):594-605
J:204641 Vizlin-Hodzic D, et al., SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. PLoS One. 2011;6(12):e28049
J:239652 Cajigas I, et al., Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. Development. 2015 Aug 01;142(15):2641-52
J:283189 Alpsoy A, et al., Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem. 2018 Mar 16;293(11):3892-3903
J:291869 Zhu X, et al., HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription. Nucleic Acids Res. 2020 Jul 9;48(12):6563-6582
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:321533 Choi KM, et al., Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Cell Rep. 2021 Dec 14;37(11):110104