Sequence Detail

ID/Version

Q2LKW6 (UniProt | EBI)

Last sequence update: 2006-02-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NACHT, LRR and PYD domains-containing protein 1b allele 1 {ECO:0000303|PubMed:16429160}; EC=3.4.-.- {ECO:0000305|PubMed:23818853};Contains: RecName: Full=NACHT, LRR and PYD domains-containing protein 1b, C-terminus {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 1233 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrp1b	NLR family, pyrin domain containing 1B	40	96	3	7

Sequence references in MGI

J:99748 Boyden ED, et al., Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006;38(2):240-244
J:150357 Guarda G, et al., T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature. 2009 Jul 9;460(7252):269-73
J:159005 Terra JK, et al., Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J Immunol. 2010 Jan 1;184(1):17-20
J:168096 Moayeri M, et al., Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog. 2010;6(12):e1001222
J:186690 Lu B, et al., Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30;488(7413):670-4
J:189777 Kovarova M, et al., NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol. 2012 Aug 15;189(4):2006-16
J:192547 Liao KC, et al., Activation of the nlrp1b inflammasome by reduction of cytosolic ATP. Infect Immun. 2013 Feb;81(2):570-9
J:194517 Sastalla I, et al., Transcriptional analysis of the three Nlrp1 paralogs in mice. BMC Genomics. 2013 Mar 18;14(1):188
J:206165 Ewald SE, et al., NLRP1 is an inflammasome sensor for Toxoplasma gondii. Infect Immun. 2014 Jan;82(1):460-8
J:244194 Van Opdenbosch N, et al., Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 2014;5:3209
J:273615 Okondo MC, et al., Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5
J:306597 Xu H, et al., The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin. EMBO J. 2019 Jul 1;38(13):e101996