Sequence Detail

ID/Version

Q08857 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Platelet glycoprotein 4;AltName: Full=Glycoprotein IIIb; Short=GPIIIB;AltName: Full=PAS IV;AltName: Full=PAS-4;AltName: Full=Platelet glycoprotein IV; Short=GPIV;AltName: CD_antigen=CD36;

Provider

SWISS-PROT

Sequence

Polypeptide 472 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd36	CD36 molecule	176	104	5	22

Sequence references in MGI

J:36189 Endemann G, et al., CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 1993 Jun 5;268(16):11811-6
J:96018 Hoebe K, et al., CD36 is a sensor of diacylglycerides. Nature. 2005 Feb 3;433(7025):523-7
J:96478 Simantov R, et al., The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. Matrix Biol. 2005 Feb;24(1):27-34
J:102503 Laugerette F, et al., CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 2005 Nov 1;115(11):3177-3184
J:123605 Nassir F, et al., CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem. 2007 Jul 6;282(27):19493-501
J:149492 Drage MG, et al., TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009;258(1):29-37
J:149573 Masuda D, et al., Chylomicron remnants are increased in the postprandial state in CD36 deficiency. J Lipid Res. 2009 May;50(5):999-1011
J:154040 Jimenez-Dalmaroni MJ, et al., Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS One. 2009;4(10):e7411
J:157175 Erdman LK, et al., CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. J Immunol. 2009 Nov 15;183(10):6452-9
J:158401 Stewart CR, et al., CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010 Feb;11(2):155-61
J:176136 Martin C, et al., The Lipid-Sensor Candidates CD36 and GPR120 Are Differentially Regulated by Dietary Lipids in Mouse Taste Buds: Impact on Spontaneous Fat Preference. PLoS One. 2011;6(8):e24014
J:205721 Sheedy FJ, et al., CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013 Aug;14(8):812-20
J:208972 Le Foll C, et al., FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes. 2013 Aug;62(8):2709-16
J:225405 Gaillard D, et al., The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 2008 May;22(5):1458-68
J:225484 Tran TT, et al., Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem. 2011 Jul 15;286(28):25201-10
J:227372 Heit B, et al., Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25;24(4):372-83
J:230545 Cui W, et al., Interaction of thrombospondin1 and CD36 contributes to obesity-associated podocytopathy. Biochim Biophys Acta. 2015 Jul;1852(7):1323-33
J:270120 Wang J, et al., DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep. 2019 Jan 2;26(1):209-221.e5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89