Sequence Detail

ID/Version

Q07832 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase PLK1; EC=2.7.11.21 {ECO:0000269|PubMed:22405274};AltName: Full=Polo-like kinase 1; Short=PLK-1;AltName: Full=Serine/threonine-protein kinase 13; Short=STPK13;

Provider

SWISS-PROT

Sequence

Polypeptide 603 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plk1	polo like kinase 1	131	114	3	23

Sequence references in MGI

J:12876 Clay FJ, et al., Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4882-6
J:20466 Hamanaka R, et al., Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase. Cell Growth Differ. 1994 Mar;5(3):249-57
J:28603 Lake RJ, et al., Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. Mol Cell Biol. 1993 Dec;13(12):7793-801
J:142593 Lu LY, et al., Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol. 2008 Nov;28(22):6870-6
J:183245 Mondal G, et al., Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mol Cell. 2012 Mar 9;45(5):680-95
J:216866 Kim J, et al., Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature. 2015 Jan 22;517(7535):466-71
J:239231 Zhang B, et al., DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J Biol Chem. 2017 Jan 27;292(4):1351-1360
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320154 Lee KH, et al., Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. J Biol Chem. 2018 Jan 19;293(3):847-862