Sequence Detail

ID/Version

Q04888 O09141 P70416 O08518 O54856 (UniProt | EBI)

Last sequence update: 1999-07-15
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Transcription factor SOX-10;AltName: Full=Protein SOX-21;AltName: Full=Transcription factor SOX-M;

Provider

SWISS-PROT

Sequence

Polypeptide 466 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sox10	SRY (sex determining region Y)-box 10	80	248	3	33

Sequence references in MGI

J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
J:36018 Stock DW, et al., Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996 Oct 15;37(2):234-7
J:37842 Tani M, et al., Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells. Genomics. 1997 Jan 1;39(1):30-7
J:45117 Southard-Smith EM, et al., Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat Genet. 1998 Jan;18(1):60-4
J:47640 Herbarth B, et al., Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5161-5
J:50203 Pusch C, et al., The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum Genet. 1998 Aug;103(2):115-23
J:149914 Mou Z, et al., The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. J Biol Chem. 2009 May 15;284(20):13629-40
J:205136 Hornig J, et al., The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet. 2013 Oct;9(10):e1003907
J:231103 Baroti T, et al., Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. J Neurochem. 2016 Jan;136(2):316-28
J:236148 Muth KN, et al., The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Glia. 2016 Dec;64(12):2120-2132