Sequence Detail

ID/Version

Q02152 Q9QWS2 Q8JZK5 (UniProt | EBI)

Last sequence update: 2013-10-16
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=5-hydroxytryptamine receptor 2B; Short=5-HT-2B; Short=5-HT2B;AltName: Full=5-HT-2F;AltName: Full=NP75 protein;AltName: Full=Serotonin receptor 2B;

Provider

SWISS-PROT

Sequence

Polypeptide 479 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	122	112	3	16

Sequence references in MGI

J:3106 Loric S, et al., New mouse 5-HT2-like receptor. Expression in brain, heart and intestine. FEBS Lett. 1992 Nov 9;312(2-3):203-7
J:64067 Nebigil CG, et al., Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9508-13
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:79276 Launay JM, et al., Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat Med. 2002 Oct;8(10):1129-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103344 Nebigil CG, et al., Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function. Circulation. 2001 Jun 19;103(24):2973-9
J:112719 Launay JM, et al., Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB J. 2006 Sep;20(11):1843-54
J:118464 Nebigil CG, et al., Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. FASEB J. 2003 Jul;17(10):1373-5
J:133019 Doly S, et al., Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro. J Neurosci. 2008 Mar 12;28(11):2933-40
J:134798 Collet C, et al., The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. FASEB J. 2008 Feb;22(2):418-27
J:163130 Janoshazi A, et al., Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol Pharmacol. 2007 Jun;71(6):1463-74
J:167209 Bevilacqua L, et al., A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature. 2010 Dec 23;468(7327):1061-6
J:310964 Tharayil VS, et al., Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil. 2010 Apr;22(4):462-9, e109-10