Sequence Detail

ID/Version

P97378 B9EHD9 (UniProt | EBI)

Last sequence update: 1997-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-12 receptor subunit beta-2; Short=IL-12 receptor subunit beta-2; Short=IL-12R subunit beta-2; Short=IL-12R-beta-2; Short=IL-12RB2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 874 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il12rb2	interleukin 12 receptor, beta 2	26	99	3	12

Sequence references in MGI

J:37050 Presky DH, et al., A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14002-7
J:70821 Poltorak A, et al., A point mutation in the il-12rbeta2 gene underlies the il-12 unresponsiveness of lps-defective c57bl/10sccr mice. J Immunol. 2001 Aug 15;167(4):2106-11
J:79543 Nishikomori R, et al., Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12Rbeta2 chain expression and signaling. J Immunol. 2002 Oct 15;169(8):4388-98
J:331607 Szabo SJ, et al., Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med. 1997 Mar 3;185(5):817-24