Sequence Detail

ID/Version

P70365 Q66JL7 P70366 Q8CBI9 Q61202 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor coactivator 1; Short=NCoA-1; EC=2.3.1.48;AltName: Full=Nuclear receptor coactivator protein 1; Short=mNRC-1;AltName: Full=Steroid receptor coactivator 1; Short=SRC-1;

Provider

SWISS-PROT

Sequence

Polypeptide 1447 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ncoa1	nuclear receptor coactivator 1	112	114	3	169

Sequence references in MGI

J:32922 Kamei Y, et al., A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14
J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
J:42693 Yao TP, et al., The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10626-31
J:45951 Zhu Y, et al., Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma. Gene Expr. 1996;6(3):185-95
J:46528 Xu J, et al., Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998 Mar 20;279(5358):1922-5
J:64957 Chen D, et al., Regulation of transcription by a protein methyltransferase. Science. 1999 Jun 25;284(5423):2174-7
J:80975 Picard F, et al., SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues. Cell. 2002 Dec 27;111(7):931-41
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116733 Xie H, et al., RORgammat recruits steroid receptor coactivators to ensure thymocyte survival. J Immunol. 2005 Sep 15;175(6):3800-9
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:222684 Wansa KD, et al., The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003 Jul 4;278(27):24776-90
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87