Sequence Detail

ID/Version

P70335 Q8C7H0 Q8C3G4 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Rho-associated protein kinase 1; EC=2.7.11.1;AltName: Full=Rho-associated, coiled-coil-containing protein kinase 1;AltName: Full=Rho-associated, coiled-coil-containing protein kinase I; Short=ROCK-I;AltName: Full=p160 ROCK-1;

Provider

SWISS-PROT

Sequence

Polypeptide 1354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rock1	Rho-associated coiled-coil containing protein kinase 1	144	112	3	24

Sequence references in MGI

J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
J:98250 Shimizu Y, et al., ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:157776 Vemula S, et al., ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood. 2010 Mar 4;115(9):1785-96
J:175678 Brunner M, et al., Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011 Jul 25;194(2):307-22
J:196103 Alvarez B, et al., Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions. J Cell Physiol. 2008 Feb;214(2):474-82
J:196108 Stroeken PJ, et al., Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. J Cell Physiol. 2006 Sep;208(3):620-8
J:197789 Mohan S, et al., Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction. Mol Biol Cell. 2012 Jun;23(11):2131-42
J:278520 Wang L, et al., Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). Sci Rep. 2018 Aug 16;8(1):12286
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89