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Sequence Detail
P70335 Q8C7H0 Q8C3G4 (UniProt | EBI) Last sequence update: 1997-02-01
Last annotation update: 2019-07-03
from provider
RecName: Full=Rho-associated protein kinase 1; EC=;AltName: Full=Rho-associated, coiled-coil-containing protein kinase 1;AltName: Full=Rho-associated, coiled-coil-containing protein kinase I; Short=ROCK-I;AltName: Full=p160 ROCK-1;
Polypeptide 1354 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Rock1 Rho-associated coiled-coil containing protein kinase 1 84 12 9 19
Sequence references in MGI J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
J:98250 Shimizu Y, et al., ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:157776 Vemula S, et al., ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood. 2010 Mar 4;115(9):1785-96
J:175678 Brunner M, et al., Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011 Jul 25;194(2):307-22
J:196103 Alvarez B, et al., Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions. J Cell Physiol. 2008 Feb;214(2):474-82
J:196108 Stroeken PJ, et al., Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. J Cell Physiol. 2006 Sep;208(3):620-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory