Sequence Detail

ID/Version

P63158 P27428 P07155 P27109 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=High mobility group protein B1;AltName: Full=High mobility group protein 1; Short=HMG-1;

Provider

SWISS-PROT

Sequence

Polypeptide 215 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hmgb1	high mobility group box 1	157	138	5	20

Sequence references in MGI

J:1523 Yotov WV, et al., Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1). Nucleic Acids Res. 1992 Jul 11;20(13):3516
J:16826 Pauken CM, et al., Molecular cloning, expression analysis, and chromosomal localization of mouse Hmg1-containing sequences. Mamm Genome. 1994 Feb;5(2):91-9
J:21498 Ferrari S, et al., The mouse gene coding for high mobility group 1 protein (HMG1). J Biol Chem. 1994 Nov 18;269(46):28803-8
J:55880 Calogero S, et al., The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice [see comments]. Nat Genet. 1999 Jul;22(3):276-80
J:100818 Najima Y, et al., High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding. J Biol Chem. 2005 Jul 29;280(30):27523-32
J:124613 Prasad R, et al., HMGB1 Is a Cofactor in Mammalian Base Excision Repair. Mol Cell. 2007 Sep 7;27(5):829-41
J:126243 Mitola S, et al., Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine. J Immunol. 2006 Jan 1;176(1):12-5
J:139020 Lange SS, et al., High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10320-5
J:140694 Youn JH, et al., Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J Immunol. 2006 Dec 1;177(11):7889-97
J:146403 Ivanov S, et al., A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood. 2007 Sep 15;110(6):1970-81
J:154027 Yanai H, et al., HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 2009 Nov 5;462(7269):99-103
J:164216 Lamkanfi M, et al., Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol. 2010 Oct 1;185(7):4385-92
J:176086 Tang D, et al., High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab. 2011 Jun 8;13(6):701-11
J:182700 Schiraldi M, et al., HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med. 2012 Mar 12;209(3):551-63
J:187594 Chiba S, et al., Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol. 2012 Jul 29;13(9):832-42
J:194127 He Y, et al., Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2013 Jan 15;73(2):629-39
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:205499 Yanai H, et al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20699-704
J:210631 Huebener P, et al., High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab. 2014 Mar 4;19(3):539-47
J:220375 Zhu X, et al., Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 2;125(3):1098-110
J:220512 Tang D, et al., Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010 Sep 6;190(5):881-92
J:223833 Li X, et al., Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. Mol Immunol. 2015 May;65(1):177-88
J:233938 Park JS, et al., High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol. 2006 Mar;290(3):C917-24
J:244884 Chen GY, et al., CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009 Mar 27;323(5922):1722-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89