Sequence Detail

ID/Version

P57080 Q80ZT9 (UniProt | EBI)

Last sequence update: 2004-04-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ubiquitin carboxyl-terminal hydrolase 25; EC=3.4.19.12;AltName: Full=Deubiquitinating enzyme 25;AltName: Full=Ubiquitin thioesterase 25;AltName: Full=Ubiquitin-specific-processing protease 25; Short=mUSP25;

Provider

SWISS-PROT

Sequence

Polypeptide 1055 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Usp25	ubiquitin specific peptidase 25	44	106	3	23

Sequence references in MGI

J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
J:226812 Lin D, et al., Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11324-9
J:235021 Ren Y, et al., The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene. J Biol Chem. 2016 Jun 17;291(25):13206-15
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:340706 Cai C, et al., USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice. Nat Commun. 2023 Jun 20;14(1):3648