Sequence Detail

ID/Version

P55086 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Proteinase-activated receptor 2; Short=PAR-2;AltName: Full=Coagulation factor II receptor-like 1;AltName: Full=G-protein coupled receptor 11;AltName: Full=Thrombin receptor-like 1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 399 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	F2rl1	F2R like trypsin receptor 1	145	108	4	49

Sequence references in MGI

J:23769 Nystedt S, et al., The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression. J Biol Chem. 1995 Mar 17;270(11):5950-55
J:76626 Lindner JR, et al., Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol. 2000 Dec 1;165(11):6504-10
J:85273 Ge L, et al., A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem. 2003 Sep 5;278(36):34418-26
J:85990 Seeliger S, et al., Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J. 2003 Oct;17(13):1871-85
J:96312 Damiano BP, et al., Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther. 1999 Feb;288(2):671-8
J:106127 Kawagoe J, et al., Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. Jpn J Pharmacol. 2002 Jan;88(1):77-84
J:107490 Su X, et al., Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15;175(4):2598-605
J:119195 Noorbakhsh F, et al., Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J Exp Med. 2006 Feb 20;203(2):425-35
J:127763 Kaneider NC, et al., 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol. 2007 Dec;8(12):1303-12
J:166198 Ramelli G, et al., Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology. 2010 Jan;129(1):20-7
J:175344 McCoy KL, et al., PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol Pharmacol. 2010 Jun;77(6):1005-15