Sequence Detail

ID/Version

P48356 Q9QWG3 Q64309 O54986 Q61215 O35686 Q9QWV5 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Leptin receptor; Short=LEP-R;AltName: Full=B219;AltName: Full=OB receptor; Short=OB-R;AltName: CD_antigen=CD295;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1162 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lepr	leptin receptor	69	118	3	72

Sequence references in MGI

J:30407 Tartaglia LA, et al., Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995 Dec 29;83(7):1263-71
J:31324 Chen H, et al., Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996 Feb 9;84(3):491-5
J:31327 Lee GH, et al., Abnormal splicing of the leptin receptor in diabetic mice. Nature. 1996 Feb 15;379(6566):632-5
J:33785 Cioffi JA, et al., Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med. 1996 May;2(5):585-9
J:33833 Ghilardi N, et al., Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6231-5
J:43353 Igel M, et al., Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. Endocrinology. 1997 Oct;138(10):4234-9
J:44004 Chua SC Jr, et al., Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics. 1997 Oct 15;45(2):264-70
J:49623 Lord GM, et al., Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998 Aug 27;394(6696):897-901
J:53637 Igel M, et al., Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain. J Mol Endocrinol. 1998 Dec;21(3):337-45
J:60001 Ducy P, et al., Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000 Jan 21;100(2):197-207
J:82334 Bates SH, et al., STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003 Feb 20;421(6925):856-9
J:109736 Hileman SM, et al., Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology. 2002 Mar;143(3):775-83
J:219525 Flak JN, et al., Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. Nat Neurosci. 2014 Dec;17(12):1744-50
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89