Sequence Detail

ID/Version

P31230 Q60659 (UniProt | EBI)

Last sequence update: 2001-10-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;AltName: Full=Multisynthase complex auxiliary component p43;Contains: RecName: Full=Endothelial monocyte-activating polypeptide 2; Short=EMAP-2; AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 310 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aimp1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	39	103	4	46

Sequence references in MGI

J:20657 Kao J, et al., Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem. 1994 Oct 7;269(40):25106-19
J:93041 Kim JY, et al., p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7912-6
J:95974 Park SG, et al., The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am J Pathol. 2005 Feb;166(2):387-98
J:114694 Park SG, et al., Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14913-8
J:122196 Han JM, et al., Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. Am J Pathol. 2007 Jun;170(6):2042-54
J:127945 Shalak V, et al., The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. J Biol Chem. 2001 Jun 29;276(26):23769-76
J:131572 Kim E, et al., AIMP1/p43 Protein Induces the Maturation of Bone Marrow-Derived Dendritic Cells with T Helper Type 1-Polarizing Ability. J Immunol. 2008 Mar 1;180(5):2894-902
J:136721 Lee YS, et al., AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. Biochem Biophys Res Commun. 2008 Jul 4;371(3):395-400
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89