Sequence Detail

ID/Version

P28334 (UniProt | EBI)

Last sequence update: 1992-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=5-hydroxytryptamine receptor 1B; Short=5-HT-1B; Short=5-HT1B;AltName: Full=Serotonin receptor 1B;

Provider

SWISS-PROT

Sequence

Polypeptide 386 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	74	104	3	12

Sequence references in MGI

J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
J:20209 Saudou F, et al., Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science. 1994 Sep 23;265(5180):1875-8
J:43716 Trillat AC, et al., Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. J Neurochem. 1997 Nov;69(5):2019-25
J:60039 Sarhan H, et al., 5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes: further evidence using 5-HT moduline, polyclonal 5-HT1B receptor antibodies and 5-HT1B receptor knock-out mice. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):12-8
J:112765 Rutz S, et al., Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain Res Bull. 2006 Jun 15;70(1):81-93
J:118053 Pineyro G, et al., Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice. Neuroreport. 1995 Dec 29;7(1):353-9
J:163130 Janoshazi A, et al., Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol Pharmacol. 2007 Jun;71(6):1463-74