Sequence Detail

ID/Version

P23949 Q3TCE3 B9EIF6 Q3TU59 (UniProt | EBI)

Last sequence update: 2013-09-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=mRNA decay activator protein ZFP36L2 {ECO:0000305};AltName: Full=Butyrate response factor 2 {ECO:0000250|UniProtKB:P47974};AltName: Full=TPA-induced sequence 11d {ECO:0000303|PubMed:1996120};AltName: Full=Zinc finger protein 36, C3H1 type-li

Provider

SWISS-PROT

Sequence

Polypeptide 484 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zfp36l2	zinc finger protein 36, C3H type-like 2	68	104	3	9

Sequence references in MGI

J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
J:75684 Phillips RS, et al., Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem. 2002 Mar 29;277(13):11606-13
J:98334 Ramos SB, et al., The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development. Development. 2004 Oct;131(19):4883-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:152911 Stumpo DJ, et al., Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 2009 Sep 17;114(12):2401-10
J:162388 Hodson DJ, et al., Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol. 2010 Aug;11(8):717-24
J:184370 Ramos SB, Characterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility. J Biol Chem. 2012 Apr 13;287(16):13116-27
J:199080 Zhang L, et al., ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature. 2013 Jul 4;499(7456):92-6
J:217353 Ball CB, et al., The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation. PLoS One. 2014;9(5):e97324
J:218843 Cargnin F, et al., An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST. J Neurosci. 2014 Dec 10;34(50):16650-61
J:232475 Galloway A, et al., RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. Science. 2016 Apr 22;352(6284):453-9
J:233560 Tan FE, et al., Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1740-8
J:233569 Lin NY, et al., Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. Int J Biol Sci. 2012;8(5):761-77
J:244789 Hausburg MA, et al., Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. Elife. 2015 Mar 27;4:e03390