Sequence Detail

ID/Version

P21784 (UniProt | EBI)

Last sequence update: 1998-07-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=V(D)J recombination-activating protein 2; Short=RAG-2;

Provider

SWISS-PROT

Sequence

Polypeptide 527 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rag2	recombination activating gene 2	44	106	3	43

Sequence references in MGI

J:1935 Shinkai Y, et al., RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992 Mar 6;68(5):855-67
J:10580 Oettinger MA, et al., RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science. 1990 Jun 22;248(4962):1517-23
J:58995 Landree MA, et al., Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev. 1999 Dec 1;13(23):3059-69
J:145466 Stetson DB, et al., Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 2008 Aug 22;134(4):587-98
J:149451 Hewitt SL, et al., RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 2009 Jun;10(6):655-64
J:159059 Yin FF, et al., Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol. 2009 May;16(5):499-508
J:159138 Matthews AG, et al., RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13;450(7172):1106-10
J:159139 Ramon-Maiques S, et al., The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18993-8
J:159157 Elkin SK, et al., A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem. 2005 Aug 5;280(31):28701-10